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The hepatoprotective activity is due to the presence of chlorogenic acid CGA isolated from the Cadamba plant. Mondal et al. They have reported that the methanolic extract of Cadamba bark showed significant increase in urinary output as compared to aqueous, chloroform, and petroleum ether extracts. The Cadamba is an important plant having tremendous medicinal properties. This review has showcased various biological and pharmacological activities of the Cadamba.

Particularly, the leaves and bark have great significance. Most surprisingly, despite the Cadamba being a miraculous plant, very few studies have been done. There are very few derived products from the Cadamba known so far that have been commercialized or been recommended in daily life for people. There is an urgent requirement for intensive studies on this plant to exploit it for the treatment of various incurable diseases prevalent across the world.

Alka Dwevedi is thankful to authors, Kuldeep Sharma and Yogesh K Sharma for their efforts in collection of literature on biological and pharmacological activities as well as chemical structures of various phytochemicals of Cadamba. Conflict of Interest: All authors have none to declare.

National Center for Biotechnology Information , U. Journal List Pharmacogn Rev v. Pharmacogn Rev. Author information Article notes Copyright and License information Disclaimer. Address for correspondence: Dr. E-mail: moc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. This article has been cited by other articles in PMC. Abstract The Cadamba is one of the important medicinal plants belonging to the Rubiaceae family.

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Keywords: Anticancer, antioxidant, Cadamba , pharmacology, phytochemical. Open in a separate window.

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Figure 1. Figure 3. Figure 2. Significance Astroethnobotanical importance According to mythology, the whole universe is made of five elements or panchtatva fire, earth, air, soil, and water , including plants and animals. Antivenom activity Snakebite is one of the major causes of the high mortality rate in India and other developing countries. Antioxidant activity Studies on antioxidants are crucial, particularly in the food industry and in therapeutic research. Biological significance Antihelminthic activity Recently, the antihelminthic activity of the Cadamba has been elucidated.

Antifungal activity Patel et al. Antifilarial and antimalarial activities Mosquito-borne diseases like malaria, dengue, chikungunya, filariasis, and Japanese encephalitis cause thousands of deaths per year in India as well as in other developing countries.

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Pharmacological significance of phytochemicals of Cadamba Antidiabetic activity Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and alterations in carbohydrate, fat, and protein metabolism. Figure 4. In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method. Trop Biomed. Screening of some Indian medicinal plants for their antimicrobial properties. J Ethnopharmacol. Screening of Indian plants for biological activity. Indian J Exp Biol. Medicinal plants and antimicrobial activity.

Preliminary phytochemical screening and evaluation of in vitro antioxidant activity of Anthocephalous cadamba by using solvent extracts. Eur J Biol Sci. Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutr Cancer. Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug. Cancer Lett. Medical ethnobotany of the siddis of Uttara Kannada district, Karnataka, India. Antimicrobial, wound healing and antioxidant activities of Anthocephalus Cadamba. Antidiarrhoeal property of the hydroethanolic extract of the flowering tops of Anthocephalus cadamba.

Rev Bras Farmacogn. Banerji N. Structure of two new saponins from stem bark of Anthocephalus cadamba MIQ. J Indian Chem Soc. Anthocephalus alkaloids: Cadamine and isocadamine. Tetrahedron Lett. Pharmacognostical studies on the leaf of Neolamarckia cadamba Roxb. Bosser, Rubiaceae.

J Econ Taxon Bot. Anthocephalus cadamba : A Review. Pharmacog J. Phytochemical composition and antioxidant properties of methanol extracts of leaves and fruits of Neolamarckia cadamba Roxb. J Biol Act Prod Nature.

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Heart wood of cadamba contains glucoalkaloids of isodihydrocadambien. New saponins from stem bark of Anthocephalus cadamba MIQ. Indian J Chem B. Joshi S, Gupta S. Astroethnobotany: Relationship of plants, planets and nakshtra. Indian J Appl Pure Biol. Etanomedicinal claims on antivenom activity of certain fruit and seed drugs-a review.

Halliwell B, Gutteridge JM. The antioxidants of human extracellular fluids. Arch Biochem Biophys.

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Endogenous antioxidants and radical scavengers. Adv Exp Med Biol. Individual and combined antioxidant effects of seven phenolic agents in human erythrocyte membrane ghosts and phosphatidylcholine liposome systems: Importance of the partition coefficient. J Agric Food Chem. Antioxidant secoiridoids from fringe tree Chionanthus virginicus L. Wood Sci Technol. Bixin and lycopene modulation of free radical generation induced by cisplatin-DNA interaction. Food Chem.

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Halliwell B. Dietary polyphenols: Good, bad, or indifferent for your health? Cardiovascular Res. Carcinogenicity of butylated hydroxyanisole in F rats. J Natl Cancer Inst. Phytochemical studies and antioxidant activity of different leaves extracts of A. Asian Pac J Trop Med. Screening of Anthocephalus cadamba roxb. Dogra SC. Antimicrobial agents used in ancient India. Indian J Hist Sci. Anthelmintic activity of Bacopa monierri. Indian J Nat Prod. Evaluation of antifungal activity of Neolamarckia cadamba roxb.

Int Res J Pharm. Bioefficacy of plant-mediated gold nanoparticles and Anthocepholus cadamba on filarial vector, Culex quinquefasciatus Insecta: Diptera: Culicidae Parasitol Res. Bioactivity screening of crude alkaloidal extracts from some rubiaceae. Chiang Mai Univ J. Mishra RP, Siddique L. Antibacterial properties of Anthocephalus cadamba fruits. Asian J Plant Sci Res. Antibacterial properties of some plants-extracts against plant pathogenic bacteria Rathyibacter tritici.

Antimicrobial activity of Anthocephalus cadamba Linn. J Chem Pharm Res. Diabetes Mellitus.